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Articles

by TANG Haitao, HUANG Wenlong, MA Jimei, LIU Li
7 Views, 5 PDF Downloads

With the increasing recognition of TCM (traditional Chinese medicine) from people thanks to its characteristics and merits, more and more countries are beginning to pay close attention to the development and application of TCM. Though TCM has been spread to numerous countries and regions, only a few TCM drugs have been registered as medications in the mainstream markets in Europe and the U.S., which are also the important overseas markets in the global ambition of TCM enterprises from China. By selecting typical cases and, in particular, studying the cases of Tasly Compound Danshen Dripping Pills entering the U.S. market and Di’ao Xinxuekang Capsule entering the EU market, this paper compares the processes and experience of TCM registration in the form of vegetable drug in the U.S. and the EU in order to provide practical and feasible references for TCM to attempt the EU and U.S. markets.

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Articles

by Abdul Gbaj
13 Views, 12 PDF Downloads

We investigated the anti-Cerastes cerastes venom effect of aqueous olive leaf extract. The mitigation in the mean survival time of the albino mice were used to deduce the antivenom property of this extract after challenging with LD99 of snake venom. The aqueous extract of olive leaf significantly increases the mean survival time and the protection fold, but could not protect animals from death when used alone. The higher dose, i.e., 33 g/kg was found better than that of the lower dose of 15 g/kg. The anti-snake venom was found to be more efficient than the aqueous olive leaf extract.

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Review Article

by Anita Aperia, Jorgen Dirach, Mike Hardman, Christa Janko, Jeff Kipling, Rosan Kreeftmeijer-Vegter, Rebecca Ludwig, Lena Scott, Armel Stockis
262 Views, 196 PDF Downloads

“No research without trained researchers” has become the mantra of the EU-funded Innovative Medicines Initiative (IMI) education and training projects. However, it is often hard to determine the type of training required at different stages of a scientist’s career. The situation is further complicated by the constantly changing environment, e.g. the growth of disruptive technologies, societal expectations of biomedical sciences, the greater need for multi-disciplinary collaborations, and conservative or changing regulatory requirements. This article summarises the experience from a series of five EMTRAIN Public Private Partnership PhD workshops that included both scientific and transferrable skill training. This is followed by an example of a recently developed training programme, including a competency profile, for translational research and medicines development; the C-COMEND teaching programme. The emphasis is on competencies as a new currency for continuing professional development. Finally, this paper describes what we consider to be the next steps required by the scientific community to address solutions to the current training challenges so that society can benefit from the innovations that only science can provide.

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Review Article

by Akiko Kishi, Ichiro Uchida, Daisuke Koide, Kyoko Imamura
273 Views, 259 PDF Downloads

Development of new medicines has become increasingly difficult with less possibility of success in seeds-finding and ever rising operational costs. Failure to comply with ethical standards for human research protection also erodes social trust in clinical development. In order to develop competence of professionals in medicines development such as clinical investigators and drug development scientists, a variety of educational courses and training programs have been developed and executed worldwide. As Japan is no exception and shares the same concerns, significant governmental and non-governmental efforts have been made to invest in the development of academic educational courses and adherence to international standards. This article introduces examples of the adoption of technologies to realize a user-friendly and sustainable learning management as well as an adaptation of syllabuses and core curricula to meet international standards in the era of global medicines development.

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Review Article

by Xiaoqing Wang, Huiying Zhang
1 Views, 0 PDF Downloads

Objective: To set up the HPLC method in determination of the genistin content in Flemingia philippinensis Merr. et Rolfe. Method: Extract and filter the crushed Flemingia philippinensis Merr. et Rolfe that has been soaked in methanol, the filtrate of which is to be taken out as the sample. Shimadzu LC-2010A is adopted in this experiment which is performed on Agilent Extend-RP column with acetonitrile-0.1% phosphoric acid aqueous solution (19:81) as mobile phase. The flow rate is 1.0 mL/min and the UV detective wavelength is 262 nm. Result: The linear relationship is excellent with higher recovery rate within the range. This method is rapid, simple and accurate.

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Original Research Article

by Hussam W Al-Humadi
8 Views, 5 PDF Downloads
Background: Vitamin D (VD) deficiency and serum calcium level has undefined relation with hyperemesis gravidarum (HG) during pregnancy. The present study objective was to investigate the levels of VD and calcium in pregnant women with HG and their effects on their obstetric health. Methods: This is a cross-sectional study including 97 pregnant participants with HG. The demographic data including previous and current obstetrical history and body mass index were collected by well-trained researcher following structured questionnaire after obtaining their verbal consent. Laboratory Investigations were done with estimation of VD and calcium. Results: The deficient VD among participant was 84% and low calcium was 54% .There was no significant difference with high correlation between women with low VD and those with normal regarding status of pregnancy and regarding anemia and dietary history (r2=1.0). On the other hand, there was no significant difference with weak correlation between women with low VD and calcium regarding the parity (VD:r2=0.46;calcium:r2=0.03). Moreover, women with normal VD and calcium were less likely to report a history of miscarriage. Conclusion: There was relationship between VD deficiency and HG with low calcium that might be associated with the insignificantly increasing the complication of pregnancy like miscarriage and fetal death. Furthermore, pre-pregnancy dietary intake might influence the severity of HG during following pregnancy
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Position Article

by Alan Boyd, Peter Stonier, Konrad Obiora, Ben Cottam
234 Views, 294 PDF Downloads

The Faculty of Pharmaceutical Medicine was established in the United Kingdom (UK) in 1989 to develop and maintain competence, ethics and the highest professional standards of practice in the discipline. This article charts the founding principles and history of the Faculty, details its composition and membership, and outlines the major functions and achievements of the organisation in the context of the development of the discipline of pharmaceutical medicine. The recognition of pharmaceutical medicine as a medical specialty in the UK is described together with the associated certification programme Pharmaceutical Medicine Specialty Training, which enables pharmaceutical physicians to become certified practitioners in the specialty with the UK General Medical Council (UK GMC).

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Conference Highlights

by Dipak Kalra, Mats Sundgren, Brecht Claerhout, Pierre Meulien, Bart Vannieuwenhuyse, Peter Singleton, Terje Peetso, Veli Stroetmann, Petra Wilson, Mary Baker, Pascal Coorevits, John O’Brien, Georges De Moor
275 Views, 180 PDF Downloads

The European Institute for Innovation through Health Data (i~HD) has been formed as one of the sustainable entities arising from the Electronic Health Records for Clinical Research (EHR4CR) and SemanticHealthNet projects, in collaboration with other European Commission projects and initiatives. The vision of i~HD is to become the European organisation of reference for guiding and catalysing the best, most efficient and trustworthy uses of health data and interoperability, for optimizing health and knowledge discovery.

i~HD has been established in recognition that there is a need to tackle areas of challenge in the successful scaling up of innovations that rely on high-quality and interoperable health data, to sustain and propagate the results of eHealth research, and to address current-day obstacles to using health data. i~HD was launched at an inaugural conference in Paris, in March 2016. This was attended by over 200 European clinicians, healthcare providers and researchers, representatives of the pharma industry, patient associations, health professional associations, the health ICT industry and standards bodies. The event showcased issues and approaches, that are presented in this paper to highlight the activities that i~HD intends to pursue as enablers of the better uses of health data, for care and research.

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