News: A 'homing system' targets therapeutic T-cells to brain cancer

A multi-institution international team led by researchers at Baylor College of Medicine has developed a new strategy to overcome one of the main obstacles in the treatment of brain cancer -- access to the tumor. Under the influence of cancer, the blood-brain barrier diverts immune T cells that attempt to enter the brain to fight the tumor. The new discovery, published in the journal Nature, decodes the molecular cause of this immune escape mechanism and engineers T cells with a first-in-class molecule called Homing System that enables the T cells to cross the impervious cancer blood-brain barrier to effectively fight tumors.  
Posted: 2018-09-11

News: Unexpected cell population key to blood cancer relapse


McMaster University researchers have provided evidence of new cancerous cells they have termed cancer regenerating cells, which are responsible for the return of acute myeloid leukemia after remission.

Current therapy is effective at inducing remission in adult patients with acute myeloid leukemia, but most patients later succumb after a relapse. That relapse has been thought to be caused by rare and dormant cancer stem cells that escape chemotherapy.

Posted: 2018-09-11

News: First interactive model of human cell division


Mitosis -- how one cell divides and becomes two -- is one of the fundamental processes of life. Researchers at EMBL have now produced the first interactive map of proteins that make our cells divide, allowing users to track exactly where and in which groups the proteins drive the division process forward. This first dynamic protein atlas of human cell division is published in Nature on 10 September 2018.

In 2010, a large study led by the same EMBL group identified which parts of the human genome are required for ……

Posted: 2018-09-11
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