Cancer and Tumor Review

Abstract

Purpose: (1) To investigate the expression of CaSR in papillary thyroid carcinoma, thyroid benign lesion and normal
thyroid cells by immunohistochemistry and to analyze the relationship between CaSR and papillary thyroid carcinoma.
(2) To study the difference of the expression of thyroid papillary carcinoma between calcification group and thyroid
papillary carcinoma without calcification and the difference of calcification between thyroid papillary carcinoma
and benign thyroid lesions and to analyze its significance. (3) To investigate the expression characteristics of CaSR
in blood stasis syndrome group and non-blood stasis syndrome group and to analyze the correlation between CaSR
and TCM blood gall blood stasis syndrome. Methods: Thirty patients (thyroid papillary carcinoma and 40 cases of
thyroid benign tumor) were treated with MaxvisionTM2 / HRP immunohistochemical two-step method to investigate
the effect of CaSR on thyroid papillary carcinoma, thyroid benign lesion and normal thyroid tissue. All data were
analyzed by SPSS 17.0 using nonparametric test, P <0.05 for the difference was statistically significant. Results:
The expression of CaSR in thyroid papillary carcinoma and the positive expression of CaSR in thyroid benign lesion
were statistically significant. (3) CaSR in thyroid papillary carcinoma was significantly higher than that in CaSR (P
<0.05) and the positive expression of CaSR in the calcification group of thyroid papillary carcinoma was higher than
that in benign thyroid calcification group, the difference was statistically significant. (3) The expression of CaSR in
thyroid papillary carcinoma was significantly higher than that in thyroid papillary carcinoma. There was a significant
difference in the positive expression of CaSR between blood stasis syndrome group and non - blood stasis syndrome
group (P <0.05). Conclusion: (1) CaSR in normal thyroid tissue in a small amount or no expression in papillary
thyroid carcinoma and thyroid benign lesions in the expression of thyroid papillary carcinoma in the high expression
of: (2) CaSR in the thyroid papillary carcinoma of the calcification group (P <0.05) .In conclusion, CaSR may play a
key role in the calcification of thyroid papillary carcinoma; (3) CaSR may play an important role in the calcification
of thyroid papillary carcinoma. The positive expression of blood stasis syndrome group was higher than that of nonblood
stasis syndrome group which indicated that CaSR might be correlated with Chinese medicine gall blood stasis
syndrome.