Table of Contents
Articles
by Kaplan Mones
Cancer Tumor Rev
2018
,
1(1);
doi: 10.18063/ctr.v1i1.528
261 Views,
244 PDF Downloads
Most of the enzymes are proteins and there are a few macromolecules with biocatalytic activity such as RNA and |
Articles
by Guodong Cheng
Cancer Tumor Rev
2018
,
1(1);
doi: 10.18063/ctr.v1i1.529
189 Views,
145 PDF Downloads
Objective: To investigate the changes of cell cycle and the content of P53 protein in S180 cells by using the specific |
Articles
by Mingzhu Yue
Cancer Tumor Rev
2018
,
1(1);
doi: 10.18063/ctr.v1i1.530
185 Views,
141 PDF Downloads
Purpose: (1) To investigate the expression of CaSR in papillary thyroid carcinoma, thyroid benign lesion and normal |
Articles
by Gang Yan
Cancer Tumor Rev
2018
,
1(1);
doi: 10.18063/ctr.v1i1.531
198 Views,
80 PDF Downloads
Primary hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. It is also a high |
Articles
by Xinran Zhao
Cancer Tumor Rev
2018
,
1(1);
doi: 10.18063/ctr.v1i1.532
195 Views,
287 PDF Downloads
Objective: To perform PICC catheterization in 129 hospitalized patients with chemotherapy for infusion of |
Articles
by FUNDA KOSOVA
Cancer Tumor Rev
2018
,
1(1);
doi: 10.18063/ctr.v1i1.614
233 Views,
104 PDF Downloads
Cancer is a disease caused by changes in the critical genes that control cell proliferation, differentiation, survival and apoptosis. Apoptotic cell death is an important mechanism and target for the anti-cancer treatment. A characteristic finding in many types of cancer is a reduction in apoptosis. Galectin-3 (Gal-3) is a pleiotropic lectin that plays an important role in cell proliferation, adhesion, differentiation, angiogenesis, and apoptosis. Therefore, synthetic galectin-3 inhibitors are of utmost importance for development of new antitumor therapeutic strategies. Galectin-3 is mainly found in the cytoplasm, also seen in the nucleus and can be secreted by non-classical, secretory pathways. In general, secreted galectin-3 mediates cell migration, cell adhesion and cell–cell interactions through the binding with high affinity to galactose-containing glycoproteins on the cell surface. Cytoplasmic galectin-3 exhibits anti-apoptotic activity and regulates several signal transduction pathways, whereas nuclear galectin-3 has been associated with premRNA splicing and gene expression. During the past decade, extensive progress has been made toward understanding the molecular basis for the regulation of apoptosis. In this review, we have focused on the role of galectin-3 in tumor metastasis with special emphasis on apoptosis. |